Mean Girls 2025 Cast Karen. Get in loser, we’re telling you about the full list of mean girls actors and characters from the beloved 2004 teen comedy. Mean girls (2025) cast and crew credits, including actors, actresses, directors, writers and more.

Avantika as karen shetty in “mean girls” (2025) (paramount pictures) karen shetty (avantika) karen shetty (played in the original by amanda seyfried) is the third member to round out. The original cast of 2004’s mean girls have all met their 2025 counterparts — we’re only missing an iconic reneé rapp and rachel mcadams regina george link up.